Sphingomyelinase deficiency (Niemann-Pick disease) in a Hereford calf.
نویسندگان
چکیده
A 5-month-old Hereford calf with neurologic disease was euthanatized, and a necropsy was done. No gross lesions were seen in the brain. Microscopically, neurons throughout the brain and spinal cord had distended, foamy vacuolated cytoplasm. Ultrastructure showed clear vacuoles filling the neuronal cytoplasm. A lysosomal storage disease was suspected. Sphingomyelinase deficiency was confirmed by biochemical analysis of liver and brain.
منابع مشابه
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ورودعنوان ژورنال:
- Veterinary pathology
دوره 45 2 شماره
صفحات -
تاریخ انتشار 2008